論文名「Reactivities of Hydroxycinnamic Acid Derivatives Involving Caffeic Acid toward Electrogenerated Superoxide in N,N-Dimethylformamide」がElectrochem誌（MDPI社）に掲載されました。

また、同誌のhighlightに採用されました。

Reactivity of (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid (caffeic acid), classified as a hydroxycinnamic acid (HCA) derivative, toward electrogenerated superoxide radical anion (O₂^•−) was investigated through cyclic voltammetry, in situ electrolytic electron spin resonance spectrometry, and in situ electrolytic ultraviolet–visible spectrometry in N,N-dimethylformamide (DMF), aided by density functional theory (DFT) calculations. The quasi-reversible redox of dioxygen/O₂^•− is modified in the presence of caffeic acid, suggesting that O₂^•− is scavenged by caffeic acid through proton-coupled electron transfer. The reactivities of caffeic acid toward O₂^•− are mediated by the ortho-diphenol (catechol) moiety rather than by the acryloyl group, as experimentally confirmed in comparative analyses with other HCAs. The electrochemical and DFT results in DMF suggested that a concerted two-proton-coupled electron transfer mechanism proceeds via the catechol moiety. This mechanism embodies the superior kinetics of O₂^•− scavenging by caffeic acid.

Keywords: hydroxycinnamic acid; caffeic acid; superoxide radical anion; cyclic voltammetry; electron spin resonance; proton-coupled electron transfer

Reactivities of Hydroxycinnamic Acid Derivatives Involving Caffeic Acid toward Electrogenerated Superoxide in N,N-Dimethylformamide

Tatsushi Nakayama, and Bunji Uno
Electrochem 2022, 3(3), 347-360
DOI: doi.org/10.3390/electrochem3030024